The Hope Project (THP): Understanding Parkinson's Disease

Updated: Dec 8, 2021

Parkinson’s Disease is a widely recognized neurodegenerative disorder. This disorder affects the dopamine-producing neurons, creating problems in the motor function of the body. Many adults, around the age of 60, suffer the challenges of being diagnosed with PD. Parkinson’s Disease doesn’t only affect the way the body moves, including tremors and instability, but also mental aspects, such as depression and sleep behavior disorders.


This article provides insights into the etiology (cause), neuropathology (the broad study of the branches of specialisations of the nervous system and its tissues) and management of Parkinson's disease.


What is Parkinson’s Disease?


As defined by the National Institute on Aging, PD is a brain disorder that leads to shaking, tremors, and troubles with coordination, as well as balance. Moreover, it is neurodegenerative, meaning it gradually gets worse leading to more severe symptoms. These include, but are not limited to, loss of motor function, loss of speech, and more. This disease tends to develop in 50% more men than women, and it begins evolving around the age of 60.



What are the causes of PD?


Parkinson’s Disease is mainly caused by nerve damage in the motor area of the brain. These cells usually create dopamine, an important brain chemical, however, dopamine levels are usually low in PD patients. This causes gradual loss of movement throughout the body. Moreover, Parkinson’s Disease causes a lower development of another important brain chemical, norepinephrine, which could be the cause of non-motor symptoms of PD, such as fatigue and irregular blood pressure. Some scientists have found a connection to heredity, however, the most likely cause of this disease is a combination between heredity and environmental factors, such as exposure to toxins.


What are complications related to Parkinson’s Disease?


Parkinson’s Disease as an independent disorder is not terminal. However, due to its many motor effects, there are certain complications associated with Parkinson’s Disease. A PD patient has a higher risk of falling and hurting themselves. This could be the cause of the patient's death, but sometimes patients go through hard surgeries that could be their cause of death.


How has science evolved to help PD patients?


Parkinson’s Disease affects motor-sensory areas, known as substancia niagara. A large portion of the brain remains undiscovered and therefore leading to inconclusive results. However, many neurosurgeons and neuro-technologists have focused their life studies on Parkinson's Disease, allowing extensive research. People devoted to studying PD tend to have PhD and MD’s in fields such as Neurology, Biomedical Engineering, Neurotechnology, Technical Pathology, and more.


How can technology help Parkinson’s Disease patients?


Technologies are now developing to slow down this neurodegenerative disease. Many people who pursue neuro-technology or pathologies can help expand the knowledge of Parkinson’s Disease. However, certain scientists and doctors aim to find nanotechnology that can help a PD patient’s level of motory function to increase. Through extensive research, PD patients may receive the help needed through technologies and implants developed by scientists who devote their life studies to PD.


Where can you help PD patients?


Many organizations provide information about Parkinson’s Disease. As the CDC states, the 14th cause of death in the United States is due to complications related to Parkinson’s Disease. Some organizations include The Michael J. Fox Foundation, Parkinson’s Foundation, American Parkinson’s Disease Association, and more.


Main Sources: https://www.parkinson.org/ https://www.nia.nih.gov


How can nootropics impact PD patients?

Parkinson’s Disease mainly occurs due to low levels of dopamine, therefore certain nootropics can help recreate the neuroarchitecture. Most nootropics help with the non-motor symptoms of PD patients. However, as said by Dr. Kyoko Koshibo, there have been studies that show increased movement in PD patients. Nootropics increase the brain’s supply of neurochemicals, either by increasing the oxygen supply to the brain or by stimulating nerve growth. Therefore, these help PD patients by producing more neurochemicals and allowing certain abilities, such as focus and energy, to be regained.


Conclusion


Parkinson’s Disease is a common neurodegenerative disease that affects over 200,000 people each year. It mainly affects the dopamine supply in the brain, leading to motor symptoms, such as tremors, shakes, etc. Many scientists are aiming to help patients with PD by providing new medicines, new technologies, and new nootropics. There are many ways that people can help PD patients, including donating to research, learning and sharing valid information, and helping family members or friends with PD.


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Unwired India is a neurotech-startup that aims at integrating state-of-the-art research and developments in STEM, for catalyzing the transition of Neuroscience to Neurotechnology. We develop avant-garde non-invasive neurostimulation products used to solve some of the world’s most critical global issues and challenges. Our mission is to take cutting-edge brain research directly into the lives and homes of people, thereby fostering a unique culture of sustainable neuroscience and scientific literacy in India.

  • Founded in 2020, we are the pioneers of Nootropics and non-invasive Neurotechnology devices in the country, and offer so much more than high-quality, delicious Brain Nutrition products for daily cognitive support; a full-service health and fitness startup that has become an important part of the local community, here in New Delhi, India.

  • We develop non-GMO, all-natural nootropic (smart-drug) formulations, Himalayan herb blends, and specialized amino-nutraceutical interventions and supplements for enhanced brain function, cognition, neuroinflammation, and neurodegeneration.

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The Hope Project (THP) is a neuro-disorder awareness initiative within the organisational framework of Unwired India. The initiative aims at creating and scaling awareness against the stigma, fear and apprehensions associated with Neurological disorders.


Aims: To promote and develop awareness across global masses and to emphasise the importance of early detection, in addition to fostering a healthy lifestyle- which is important in the management and treatment of these ailments.


WORK WITH US. Register at www.unwiredindia.com/team


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A friendly reminder: We've done our research, but you should too! Check our sources against your own and always exercise sound judgment.

https://www.ncbi.nlm.nih.gov/books/NBK536722/
 
https://www.ncbi.nlm.nih.gov/books/NBK470193/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517533/ 

https://pubmed.ncbi.nlm.nih.gov/31631455/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125353/ 

https://www.ncbi.nlm.nih.gov/books/NBK542224/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367535/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088077/ 


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About The Author


Raquel Paz Bergia


Leader of The Hope Project & International Growth Ambassador (Madrid, Spain)


Raquel Paz Bergia is a writer from Spain who developed an interest in Neurology at an early age. Over the last few years, she has surrounded her studies around Cognitive Biomedical Engineering. She has a passion for learning and researching degenerative diseases and their impact on the community.


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